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SCFAs inhibit pro-inflammatory cytokine (IL-6, IL-12) release from DCs via GPR109A and HDAC suppression, skewing T cell differentiation toward tolerance ( 6 Gut microbiota mechanisms in allergic asthma We delineate the multifaceted role of gut microbiota in allergic asthma pathophysiology, highlighting microbial-immune interactions as a therapeutic frontier for airway hyperreactivity, remodeling, and allergenic sensitization as shown in Figure 2

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