The progressive loss of nephrons reduces renal 1-hydroxylase activity, limiting the production of active 1,25-dihydroxyvitamin D (1,25(OH)D), whereas urinary loss of vitamin D-binding protein (VDBP) due to proteinuria further exacerbates 25(OH)D deficiency (3)
In a clinical trial half of patients receiving a 200mg dose followed by 100mg dose 2 weeks later were experiencing a clinical response to the drug at 6 weeks, with 18% in clinical remission
4,30,31 The increased cardiovascular demands during pregnancy (eg, increased cardiac output) may unmask latent hypertension, making pregnancy a cardiovascular stress test
To be used only under the guidance of a healthcare professional
It contributes to pain, fatigue, brain fog, and a host of other issues