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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
This scrambling, called disulfide exchange, produces misfolded peptides that do not function properly
But notably, the FDA made this statement in a release about bulk drug substances (ingredients used to make medicines) that it considers to pose potential significant safety risks, so KPVs lack of safety studies is a red flag in the FDAs eyes
Objective: To verify the reliability of the accelerated and long-term test results and provide a basis for the expiration date of product labels
S2CID 33994229
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