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Grunvald explains that the upcoming pill is essentially "oral Wegovy," and he says, "the effectiveness seems to be very comparable." "The disadvantage is that it has to be taken once a day and has to be taken without food in the morning with a limited amount of water, so you can't eat anything for at least 30 minutes after taking it." Meanwhile, Eli Lilly is developing an oral GLP-1 called orforglipron, which is in late-stage clinical trials
The 2025 guidelines do not, however, recommend using these medicines for type 1 diabetes due to the risk of adverse events
Certain thyroid conditions may also limit the use of GLP-1 medications
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