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The inhibitory effect of GLP-1 on glucagon secretion in vivo was observed only when the blood glucose level was equal to or higher than the fasting level, at higher blood glucose levels, the inhibition of glucagon gradually increased (Holst, 2007), and when the blood glucose concentration was less than 3.7 m mol/L, GLP-1 lost its effect on inhibiting glucagon secretion (Nauck et al., 2002)

Patrik Jonsson, EVP of Eli Lilly and president of Lilly International, said in an April 30 earnings call that while the company only has a few weeks worth of data from India on how generic semaglutide is impacting the market, it seems the generics are really stimulating the growth in the overall obesity market, and that includes [Mounjaro]. Prescriptions for Mounjaro have been 10% higher in recent weeks compared to before generic semaglutide was introduced, he added

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