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Summary Keywords melatonin, cerebral ischemia-reperfusion injury, reactive oxygen species (ROS), ischemic strokes, neuroprotective agent Citation Tozihi M, Shademan B, Yousefi H, Avci CB, Nourazarian A and Dehghan G (2023) Melatonin: a promising neuroprotective agent for cerebral ischemia-reperfusion injury

Long term safety data is limited since these compounds are not FDA approved

Increase hydration to assist in toxin elimination

Real-world adherence is substantially lower than clinical-trial completion rates, with persistence estimates ranging from approximately one-third to one-half at 1 year and substantially lower by 2 years in many analyses

Adequate hydration is critical