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Clinical Evidence: Fat Loss vs Lean Mass Preservation The body composition substudy of Retatrutides Phase 2 clinical trial provides the most comprehensive data available on how this peptide affects fat mass versus lean mass

While both compounds fall under the broad umbrella of tissue repair research, they operate on completely independent biological pathways

Thus, this matching procedure ensured that combination users and their comparators used the same background drug for the same duration and had a similar probability of receiving the treatment combination

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The mechanism here is quite complementary: GLP-1 RAs work by reducing appetite, while Metformin decreases glucose production in the liver