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In those, loss of NRF2 resulted in a more rapid onset and more severe clinical course of the EAE model, which was accompanied by increased glial activation, exacerbated spinal cord damage, and axonal degeneration as well as increased levels of proinflammatory cytokines (Johnson et al., 2010

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doi: 10.3390/healthcare10030487 170 BarcelosIPHaasRH

Onions Contain sulfur compounds that act as glutathione precursors

The prescribing information does not list B12 deficiency as a recognised adverse effect, and clinical trials have not identified a direct mechanistic link between the medication and B12 status