The antioxidant system, encompassing elements like catalase (CAT) and glutathione (GSH), endeavors to neutralize the damaging ROS but often gets overwhelmed in the process of sepsis, aggravating tissue damage and propelling the inflammatory response 13
In consequence, there is limited redox cycling of the active drug metabolite and they are less susceptible to drug-induced methaemoglobinaemia, but they are more susceptible to haemolysis (see below)
Swan, E
Though more clinical trials are needed, preclinical evidence suggests that supplementation of NAD may be promising for preventing or lessening the risk of neurodegenerative diseases
While SOD converts superoxide radical (O 2 ) into hydrogen peroxide (H 2 O 2 ), the other two enzymes, GPx or CAT, transform this highly reactive hydrogen peroxide into water (H 2 O) or water, and molecular oxygen (O 2 ), respectively