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If a freezer isn't available, a refrigerator is the next best choice, but it shortens the long-term shelf life

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Typically, the first generic will be around 75 to 85 per cent of the brand price, says Tadrous

By encapsulating pharmacological agents and natural compounds, PLGA systems could overcome the shortcomings of conventional therapies and improve the therapeutic potential of phytochemicals

A significant obstacle to achieving this is the susceptibility of probiotics to a confluence of hostile conditions, including gastric acidity, bile salts, temperature variations, and antimicrobial factors such as hydrogen peroxide, which can severely diminish their viability and functionality (273)