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For example, aluminum hydroxide salts, often used as vaccine adjuvants, have been found to abnormally persist within immune cells at the site of previous immunization, resulting in macrophagic myofasciitis lesions (168)
Histone-modifying enzymes represent key epigenetic markers
(1) Adolescence (1218 years): high sensitivity to high-sugar diets Although human studies investigating the gut microbiome in adolescents remain limited, the ongoing development of the gut-brain axis and the adolescent brain suggests that this population may be particularly susceptible to diet-induced depressive symptoms (320), The impact of high-sugar diets on metabolic and intestinal health In male C57BL/6J mice, consumption of a high-glucose diet (HGD) over a 12-week period induces hyperglycemia, glucose intolerance, dyslipidemia, and increased adipose deposition
