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In participants with obesity or overweight, withdrawing tirzepatide led to substantial regain of lost weight, whereas continued treatment maintained and augmented initial weight reduction [75]

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Consequently, the implementation of these findings to the broader population of patients who develop metabolic complications secondary to glucocorticoid therapy remains limited

This suggests GLP-1 is the key player for appetite suppression and weight loss, with GIP providing enhancement rather than being equally important

10.1007/BF02427280