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Patients with type 2 diabetes and depressive symptoms received chronic candesartan administration for at least three months, which significantly improved interpersonal sensitivity and depression ratings and reset the HPA axis by reducing the sensitivity of the adrenals to ACTH and expression of AT1R (148)

3 5 Whether it maintains a clinically meaningful gastric-emptying delay across months of once-weekly dosing is unproven, and there is a credible mechanistic reason drawn from the broader behavior of long-acting gut-hormone agonists to suspect the effect may attenuate