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Another major factor contributing to the pathophysiological mechanisms in ALS is excitotoxicity, triggered by excessive postsynaptic glutamate receptor stimulation

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Base Excess-: 6 mmol/L), and her urine-organic acid analysis showed an increase in 5-oxoproline level [400.4 (normal range: 010.0)]

Consequently, clinical manifestations, such as periventricular leukomalacia, epilepsy, cognition and memory deficiency were also present

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