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271 In early designs, CLs were permanently charged to bind the cell membrane and NADs effectively

From a mechanistic perspective, highly soluble drugs classified as BCS Class I or III generally show limited sensitivity to food intake, which is consistent with their high solubility and/or permeability, reducing dissolution-dependent variability in absorption

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doi: 10.2147/jbm.s159295

MAS, the major redox shuttle system in the brain [10], involves the concerted activity of mitochondrial and cytosolic isoforms of both glutamate-oxaloacetate transaminase (GOT) and malic dehydrogenase (MDH), along with the mitochondrial oxoglutarate/malate carrier (OGC, encoded by the SLC25A11 gene) and AGC, the rate-limiting step of the pathway [11, 12]