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Some of these effects appear to come directly from GLP-1 signaling

75.4%) compared to the DPP-4i group, although these differences were below the minimum SMD threshold of 0.2

Emerging evidence from genome-wide association studies (GWAS) and epidemiological research has linked the C677T polymorphism in the gene encoding the folate-metabolising enzyme MTHFR with an increased risk of hypertension and HDP by up to 87 %, as mentioned earlier in this review (Reference Qian, Lu and Tan15Reference Yang, Fan and Zhi18)

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