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Limitations of the STEP-HFpEF Trial Duration of Follow-Up: The trial followed participants for a specific period, and while it showed positive outcomes, the long-term effects of semaglutide still need to be studied over a more extended timeframe to ensure its safety and sustained effectiveness

The ulnar nerve runs directly behind the medial epicondyle

This was despite the methodological choice to only include patients with multiple orders for the medication to try and select for patients who were more likely to be taking the drug

It identified semaglutide-associated suicidal ideation remained significant when compared with dapagliflozin and metformin, and in the sub-group of patients with co-reported use of antidepressants and benzodiazepines

Anyone taking such medicines should discuss this with their prescriber before starting treatment