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It is primarily available for research purposes, and its use in humans carries regulatory and safety considerations

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thus, modulators of the Wnt/-catenin pathway have emerged to improve the efficacy of different immunotherapeutic agents in combination therapy, a finding that has already been researched in preclinical models

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Potential side effects Possible side effects of supplementary l-carnitine include, but are not limited to: Gut disturbance: l-carnitine does not have an established upper intake level, although doses above 3g per day may cause nausea, vomiting, abdominal cramps and diarrhoea Coronary artery disease: some research suggests l-carnitine may be linked to an increased risk of coronary artery disease and heart failure, especially in men and those who eat meat