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and in the heart and kidneys

GLP1-RA were analysed as a single homogeneous group, only allowing for the exploration of potential class effects as specific GLP1-RA had limited individual exposure

Abbreviations AMPK: 5 adenosine monophosphate-activated protein kinase CAMKK : Calcium/calmodulin-dependent protein kinase kinase CD: Cluster of differentiation CRP: C-reactive protein CXCL10: C-X-C motif chemokine 10 cAMP: Cyclic adenosine monophosphate DPP-4: Dipeptidyl peptidase-4 Erk: Extracellular signal-regulated kinase GLP-1: Glucagon-like peptide-1 HFD: High fat diet ICAM: Intercellular adhesion molecule IFN: Interferon IL: Interleukin LPS: Lipopolysaccharide MCP-1: Monocyte chemotactic protein MPTP: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyidine NF- B: Nuclear factor-kappa B NLRP3: Nucleotide-binding domain-like receptor with a pyrin domain 3 PKA: Protein kinase A PKC: Protein kinase C SIRT: Sirtuin STZ: Streptozotocin TLR4: Toll-like receptor 4 TGF- : Transforming growth factor beta TNF- : Tumor necrosis factor alpha VCAM: Vascular cell adhesion molecule

Efficacy and safety of liraglutide added to capped insulin treatment in subjects with type 1 diabetes: the adjunct two randomized trial