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First, the diluent itself

While native IGF-1 has a half-life of minutes and is tightly sequestered by binding proteins (IGFBPs), IGF-1 LR3 incorporates two critical modifications

AOD-9604: A modified fragment of human growth hormone that stimulates lipolysis without affecting blood sugar or insulin levels

[3] Given that glucocorticoids often lead to muscle wasting, the potential of GH and its secretagogues to reduce catabolic effects is an active area of research

For bone biology studies requiring absence of cortisol confounds, verify cortisol non-elevation at the experimental dose in the species and model used before attributing skeletal outcomes to GH-specific mechanisms