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Practical options include: insulated medication travel cases reusable cooling pouches (such as FRIO wallets) hotel refrigerators once you arrive When You Need a Yakkan Shmei You must apply for a Yakkan Shmei if you bring: more than a one-month supply of medication unusually large quantities of syringes certain restricted medications (not typical for GLP-1 drugs) Applications are submitted to a regional Japanese quarantine office and typically take 12 weeks to process