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Specifically, rutin can significantly upregulate the expression of ferritin heavy chain (FTH) and glutathione peroxidase 4 (GPX4), and downregulate the expression of acylCoA synthetase long-chain family member 4 (ACSL4), thereby inhibiting iron-dependent lipid peroxidation

These findings provide solid evidence that PS-MPs induce depression-like behavior in zebrafish through mechanisms involving neuroinflammation, circadian rhythm disruption, and neurotransmitter imbalances, and stressing the potential ecological risks of PS-MPs and contributing to our understanding of the neurotoxicity of microplastics

Physicians cannot prescribe it, and pharmacies cannot dispense it as a medication

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