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Extended Data Figure 4 NMR spectra of teixobactin

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Surprisingly, none of the substitutions found in these 3 bat GLP-1 sequences were confidently predicted to affect function ( Supplementary Table 8 ), however, the Gcg precursor protein sequences from two of these species (Brandts bat ( Myotis brandtii ) and little brown bat ( Myotis lucifugus )) contain amino acid substitutions at proteolytic processing sites ( Supplementary Figure 5 ) that likely impair GLP-1 7-37 production and lead to reduced levels of circulating GLP-1

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