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on 50 PCOS patients revealed a significant decrease in the total antioxidant capacity (TAC) (p0.05) compared to 45 healthy females [20]

Plasma and tissue GSH levels decline with age, while markers of oxidative damage increase, creating a "redox imbalance" implicated in the pathogenesis of age-related diseases [2][3][10][11]

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The professional consensus in dermatology is: There is reasonable evidence for short-term brightening effects and antioxidant benefits at the cellular level Long-term safety and efficacy data are insufficient to make strong, universal clinical recommendations Medical supervision, appropriate dosing, and quality-controlled formulations are the essential safeguards that separate beneficial outcomes from adverse events WebMD's guide to glutathione provides a useful overview of potential risks and interactions for further reading

Int J Mol Sci (2021) 22(11):5817