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There is consistent evidence from RCTs and real-world studies that SGLT2i use in type 1 diabetes is associated with an increased risk of DKA [14]

In Japan, where over 70% of individuals with diabetes are aged 65 or older and often exhibit a non-obese phenotype with impaired insulin secretion, dipeptidyl peptidase-4 inhibitors remain a cornerstone therapy due to their ability to enhance insulin secretion without increasing hypoglycemia risk

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