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And when they stop, the weight comes back a 2025 meta-analysis in The Lancet found that patients who discontinued semaglutide or tirzepatide regained an average of nearly 10 kilograms

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The small but significant increase in people with low blood pressure and with kidney stones are likely attributable to the fact that a combination of diarrhoea and reduced oral intake can lead some people to become somewhat fluid-depleted

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