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In addition, if you're one of the millions of Americans taking proton pump inhibitors (PPIs) that suppress stomach acid for conditions like acid reflux, you're going to be prone to vitamin B12 deficiency

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Reported biochemical potency against human NNMT is in the low-micromolar range with cellular EC values in the low-micromolar range for suppression of 1-MNA and lipogenesis, with selectivity over related methyltransferases and NAD-salvage enzymes [1,6,7]

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