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186 Transcription factor p53 is a critical mediator that is directly phosphorylated and stabilized by DNA damage signaling kinases, which triggers the apoptotic program

GSH could detoxify heterogeneous substances under the catalysis of Glutathione S-transferases (GST), then secrete them via the multidrug resistance associated proteins (MRPs) efflux pump ( 3 GSH-responsive and -exhausting metal nanomaterials 3.1 Inorganic nanomaterials Inorganic nanomaterials that have intrinsically unique physicochemical properties and can provide satisfactory functionality show enormous potential in biomedical applications, especially in cancer therapy (Wang et al., 2021a)

Kim JY, Yenari MA

This process involves the interaction of free iron ions with lipid peroxides through the Fenton reaction, leading to the production of lipid free radicals and ultimately cell death

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