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A total of ~70% GPX3 is secreted by the basolateral membrane of renal proximal tubule cells and is predominantly present in the extracellular fluid

Circulation 102:351356 Villarino AV, Kanno Y, OShea JJ (2017) Mechanisms and consequences of JakSTAT signaling in the immune system

In contrast, inflammation-related genes were upregulated in the liver and adipose tissue, although there was no significant effect with the GLP-1 analog treatments

We then hypothesized that the inefficacy of the peptide in inducing cell death in both types of cells might be attributed to inadequate cellular uptake

Deferiprone exerts a dose-dependent reduction of liver iron in adults with iron overload