1 Introduction The idea that substances produced by duodenal mucosa could stimulate and initiate pancreatic endocrine, thereby reducing the amount of urinary glucose in patients with diabetes, was first proposed in 1906 (Moore, 1906)
Plastic U-100 insulin syringe load Per injection (Fang 2024, PDMS-lubricated plastic syringe, extrapolating from their 1 mL measurement): Full 1 mL stroke: ~10-10 nanoplastic particles from PDMS lubricant alone (plus thousands of microplastics, plus whatever comes off the vial stopper during draw) Typical peptide dose is 0.1-0.3 mL, but scaling isnt linear the stopper-pierce contribution is fixed, and the plunger still travels through PDMS-coated barrel
Strong observational results can open the door to new clinical questions, but trial data will need to confirm if semaglutide truly has a direct therapeutic effect on depression, anxiety, addiction-related harm, or suicidality
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Patients were instructed to up-titrate their insulin dose in the evening based on fasting blood glucose measurements to achieve a target of 72 to 100 mg/dL