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Without water present, the degradation pathways that destroy peptides in solution, hydrolysis, deamidation, oxidation, are dramatically slowed

Obesity has impacts on cardiovascular disease outcomes through increased risk of coronary artery disease, heart failure (more prominent with preserved ejection fraction), cardiac arrhythmias (most significantly atrial fibrillation), sudden death, and venous thromboembolism [7]

These findings suggest that GLP-1 medications are doing something biologically distinct in muscle beyond simply causing weight loss

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