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Recent clinical and preclinical studies have demonstrated that metformin not only ameliorates insulin sensitivity, but also facilitates glucose-lipid reverse transport, alleviates hormone imbalances induced by glucose metabolic irregularities, and ameliorates symptoms associated with hormonal dysregulation in patients with PCOS (Shen et al., 2022

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Some research protocols also include the DSIP in a nocturnal circadian component to optimize memory consolidation

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