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In the recently published SELECT trial results, for example, semaglutide (marketed by Novo Nordisk as Wegovy for weight loss and Ozempic for type 2 diabetes) demonstrated a 20% risk reduction of heart attacks and strokes in overweight and obese individuals without diabetes and with cardiovascular disease, establishing it as a cardiovascular diseasemodifying medication in people without type 2 diabetes

It inhibits the NF-kB p65 pathway by blocking phosphorylation at Ser536 and preventing nuclear translocation

This advanced stage is associated with an elevated risk of hepatocellular carcinoma and poor patient prognosis