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The contraindications are due to health concerns

Activation of MC1R triggers a signaling cascade that pushes the melanocyte toward producing more eumelanin (brownblack pigment) over pheomelanin (redyellow pigment), and increases overall melanin content

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Most people who reach a normal weight on Ozempic or tirzepatide, Zepbound, Semaglutide, will maintain that weight if they space it out to every other week." He says he hopes to do a clinical trial in the near future