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For example, Legionella pneumophila secretes the effector SdhA, which maintains mitochondrial integrity and limits mtDNA leakage, helping the bacterium to avoid immune hyperactivation ( Beyond the cGAS-STING and NLRP3 inflammasome pathways, mtDNA also serves as a ligand for endosomal TLR9, which recognizes unmethylated CpG motifs in bacterial and mitochondrial DNA (Tripathi et al., 2023)

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The Centre for Perioperative Care (CPOC) provides guidance on managing these medications around the time of surgery, particularly due to their effects on gastric emptying

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Mean age (SD) was 53 + 14 years, 45% females, 19% T1D, 81% T2D and the racial background comprised 35% Asian, 30% White, 22% Black and 14% other/mixed