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DNA damage as measured by poly-ADP ribose polymerase (PARP) activity has also been shown to be elevated between 1 and 21 days after CCI injury in adult rodents (Satchell et al., 2003)

Variations in NOD2 receptors have been found to increase sensitivity to bacterial components and result in overproduction of inflammatory cytokines, such as -defensin, that can remove beneficial microbes from the intestinal mucosa (Swidsinski et al

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