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5-Rs isoforms (types 1, 2 and 3) are widely distributed in many tissues including the central nervous system, and inhibition of these enzymes results in blockade of synthesis of several key hormones and neuro-active steroids ( Figure ) leading to a host of adverse effects, including loss of or reduced libido, erectile dysfunction, orgasmic dysfunction, increased high Gleason grade prostate cancer (PCa), observed heart failure and cardiovascular events in clinical trials, and depression
Individuals should embrace a holistic approach, considering factors such as mental health, long-term lifestyle changes, and a supportive healthcare team
All advanced therapies are prescribed and monitored by medical professionals to ensure patient safety and alignment with evidence-based regenerative medicine practices