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GIP receptor antagonists: Although agonism is currently dominant in approved therapies, antagonists are being explored in animal models for obesity, because blockade of GIP signalling may limit lipid storage and adiposity under certain conditions

Exploring the broader metabolic landscape to advance GLP-1 agonists Leveraging the properties of glucagon-like peptide-1 (GLP-1), which has glucose-lowering effects as well as an ability to slow gastric emptying and reduce feelings of hunger, GLP-1 agonists can revive insulin excretion and improve glycemic control in individuals deficient in the naturally occurring GLP-1 hormone

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