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Dulaglutide (Trulicity): Another GLP-1 agonist used for diabetes, with potential off-label use for weight loss

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In addition, studies have found that compared with placebo, semaglutide significantly reduced AF incidence by 42% in high-cardiovascular-risk populations, and this effect was independent of administration route (oral/subcutaneous/injection), presence of underlying diabetes, and BMI (125, 127)