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However, since als3 also can be augmented in its cytotoxic potential by albumin (Fig

also indicated that, compared to other antidiabetic drugs, DPP-4 inhibitors led to an increased number of reports of gallbladder or biliary diseases, with sitagliptin accounting for up to 80% of the cases ( For GLP-1 RAs, our results indicated that although it did not show a direct correlation with biliary diseases overall, specific drugs such as semaglutide [ROR 4.06

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The two Asp's act as the main catalytic agents, and together with a water molecule cleave the protein chain bound in the tunnel