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SIRT1 is a histone deacetylase, which may regulate the transcriptional activity of BMAL1/CLOCK, forming a metabolic feedback loop again between the circadian clock system and metabolism (Nakahata et al., 2009

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It has also been pronounced that inflammatory factors such as IL-6 show a significant correlation in individuals with endometriosis complicated with infertility (Reference Wang, Ma and Song76)

While these studies show promising results, they often lack the rigor and relevance required to extrapolate findings to human subjects