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In addition, in adipose tissue, lipolysis and lipogenesis are coupled as chronic stimulation of lipolysis activates lipogenesis to match adipose tissue catabolism with anabolism (151)

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WADA and Athletic Bans MOTSc falls under WADAs Prohibited List , category S2 Classified alongside peptide hormones, growth factors, and related substances Banned in- and out-of-competition Positive tests may result in disqualification or suspension WADA prohibits all synthetic analogues of mitochondrial and peptide growth factors, including MOTS-c. World Anti-Doping Agency, Prohibited List Global Legal Overview Canada, UK, Australia : MOTSc is legal for research but not human use EU : Generally treated the same as RUO peptides

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MBOAT1 and MBOAT2 remodel PLs to protect cells from ferroptosis independent of GPX4

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Polyamines are involved in cell division and proliferation, regulation of gene expression for cell survival, facilitation of DNA and protein synthesis, apoptosis and oxidative stress control, angiogenesis, and cell-to-cell communication (Lenis et al., 2017)

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