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Tirzepatide vs Semaglutide for Metabolic Research: What the Head-to-Head Evidence Shows The most definitive head-to-head data comes from SURMOUNT-5, published in the New England Journal of Medicine in 2025

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Analogously, semaglutide protected diabetic cardiomyopathy mice against oxidative stress and apoptosis, and thereby improved cardiac dysfunction by activating Sirt1/AMPK pathway and restoring of Cx43 expression [108]