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9,10 Along with the aforementioned currently approved and evidence-based FDA indications, other disorders that may possibly receive FDA approval include heart failure with preserved ejection fraction, peripheral artery disease, arthritis, and polyendocrine metabolic ovarian syndrome (PMOS)

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Another interesting evidence has been reported about the link of IDH mutation on codon 132 or of 2-HG high levels and the higher cell invasion capacity of prostate cancer cells negative for the androgen receptor (AR)