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Interestingly, the same results were not observed in healthy age-matched mice, as 6 weeks of progressive ladder-climbing RT (3 climbs, progression from 50% to 100%MCL, 5 times per week) decreased lipid peroxidation in the cerebral cortex but increased lipid peroxidation in the hippocampus (Schimidt et al., 2019)

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By attenuating inflammation and oxidative stress, curcumin improves insulin receptor signaling and enhances insulin sensitivitymechanisms that are particularly relevant given the shared inflammatory and insulin-resistant states underlying diabetes and depression (Sarmiento-Ortega et al., 2025)