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have devised hypoxia-responsive sono-activatable semiconducting polymer nanopartners (SPNTi), which are capable of generating singlet oxygen ( 1 O 2 ) during sonodynamic therapy (SDT), thereby disrupting the surface shell to release hypoxia-responsive drugs (tirapazamine (TPZ) conjugates) and MDSC-targeting drug (ibrutinib) (115)

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In response, the brain activates the microglia which undergo morphological changes, that is, polarization to the M2 phenotype, and begin producing various inflammatory mediators, including TNF- , IL-1, and IL-6