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2 This is because most brain GLP-1 receptors are beyond the reach of these systemically administered drugs

10.1034/j.1600-079x.2003.00046.x 57 KatoH.TanakaG.MasudaS.OgasawaraJ.SakuraiT.KizakiT.et al (2015)

Like all medications, it does come with potential side effects that you should be aware of, including nausea, diarrhoea, vomiting, and decreased appetite, which are among the most commonly reported reactions

The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone

The combination is typically described as synergistic for GH pulse amplitude