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Dehydroascorbate reductase (EC 1.8.5.1), also known as glutathione dehydrogenase, is an oxi- doreductase that recycles DHA to ASC, and so limits ROS-induced damage (Gallie 2012

While ferroptosis-targeted clinical research in gastric cancer remains absent, systematic investigations of Erastin, RSL3, and the FSP1 pathway have yielded promising results in various solid tumors, establishing a preclinical research framework that integrates mechanisms, pharmacological agents, and combination strategies

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It is worth noting that the Trovato et al 315 and Caruso et al 316 studies both employed per protocol analyses, compared with the more conventional "intent to treat" methods