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Higher doses may increase gastrointestinal side effects without improving outcomes

Multiple RCTs document its efficacy in reducing visceral fat by 20% over 26 weeks

Localization of the sulfate/anion exchanger in the rat liver

Most critically, the paucity of pediatric-specific evidence cannot be overemphasized: the existing literature consists almost exclusively of case reports, with no completed RCTs specifically enrolling children with MC4R deficiency

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