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Despite prior evidence linking endogenous GLP-1 in the LS with increased satiety (30), the contribution of these GLP-1Rs to the pharmacological effects of liraglutide was unknown

A Study of Tirzepatide (LY3298176) in Participants With Nonalcoholic Steatohepatitis (NASH) (SYNERGY-NASH)

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Some patients may benefit from transitioning to lower doses of GLP-1 medications rather than complete discontinuation, though this approach requires further research to establish optimal dosing strategies